Lindner Center of Hope Research InstituteLindner Center of HOPE in affiliation with the University of Cincinnati (UC) College of Medicine conducts advanced research in genetics, brain imaging, psychopharmacology, psychotherapy, and health service delivery. This research provides new methods to better prevent, diagnose and treat common mental illnesses like schizophrenia, major depression, bipolar disorder, eating and weight disorders, anxiety disorders, attention deficit hyperactivity disorder, and cognitive and memory problems in adolescents, adults and senior individuals. Research studies and the advances they lead to are closely integrated into the evidence-based treatment programs provided at Lindner Center of HOPE. Historically, there has been a 17-year lag time before research findings are integrated with the diagnosis and treatment of patients. However, at Lindner Center of HOPE, research informs patient care each and every day.

Nationally and internationally regarded clinician-scientists at the Research Institute work in collaboration with top investigators at the University of Cincinnati College of Medicine and other leading academic research institutions around the country.

Our clinician-scientists have published over 800 scientific articles, received over $15 million in grants at UC, and $2 million in grants since opening. Lindner Center of HOPE researchers have been instrumental in bringing six new drugs to market for depression and bipolar disorder for improved therapeutic efficacy and safety.

As charter members of the National Network of Depression Centers (NNDC), the Research Institute at Lindner Center of HOPE plays a leading role in fostering breakthroughs in the field of mental health, while contributing to information sharing and rapid translation of new treatments into clinical settings of the network’s members nationwide.

In addition, the Research Institute is a member of the Harvard-based Clinical Trial Network.

Research Institute – Investigators

Susan L. McElroy, M.D., Chief Research Officer

Dr. McElroy is internationally known for her research in bipolar disorder, eating disorders, obesity, impulse control disorders and pharmacology.

A summa cum laude and Phi Beta Kappa graduate of Colgate University, Dr. McElroy received her M.D. with honors from Cornell University Medical College. She served her medical internship at Columbia Presbyterian Hospital. Dr. McElroy completed residency training in psychiatry and served on the staff at McLean Hospital and Harvard Medical School before joining the Department of Psychiatry at the University of Cincinnati College of Medicine.

Dr. McElroy has received numerous honors for her research and teaching, and has been recognized as one of America’s Top Doctors and as one of the Best Mental Health Experts by Good Housekeeping Magazine. She has authored over 500 scientific papers, reviews, book chapters and abstracts in leading medical journals and textbooks. She was the 7th most cited scientist in psychiatry and psychology from 1996-2006.


Leah Casuto, M.D., Psychiatrist

For more than 16 years Dr. Casuto has practiced psychiatry. In addition to serving patients and families in treatment settings, she has also served as a researcher and teacher in the field. She has extensive experience in community mental health serving as a staff psychiatrist for a number of facilities in Greater Cincinnati. Prior to joining Lindner Center of HOPE, Dr. Casuto focused on child, adolescent and adult therapy and psychopharmacology as an independent practitioner in a private practice.

As a researcher Dr. Casuto has worked as co-investigator on studies examining treatment of compulsive shopping and treatment of binge eating disorder. In addition, she served as co-investigator on a prospective study of children at high risk of bipolar disorder.


Anna I. Guerdjikova, PhD, MSW, LSW

Prior to joining the Research Institute at Lindner Center of HOPE, Dr. Guerdjikova was a post-doctoral fellow with the Psychopharmacology Research Program at University of Cincinnati Medical Center. She was a co-investigator, supervisor and coordinator for numerous clinical trials examining subjects with mood and eating disorders. Her main research interests are in the area of eating disorders, impulse control disorders and the overlap between mood and eating pathologies.

As part of her MSW training, Dr. Guerdjikova provided psychiatric evaluation, treatment planning and ongoing psychiatric care to patients with various psychiatric disorders, including to those with severe mental illness, anxiety disorders, chemical dependencies , and to victims of abuse and neglect.

Through Dr. Guerdjikova teaching experience she has served as a course coordinator and lecturer for medical and social work students as well as a public educator.

Dr. Guerdjikova has first and co-authored original research on the topics of binge eating disorder and obesity, pharmacotherapy of eating disorders, and specificities of bariatric surgery populations published in various peer reviewed journals. She has served as an invited reviewer of a number of professional journals, including Journal of Clinical Psychiatry, Disorders – Studies on Anorexia, Bulimia and Obesity, and Eating behaviors. Her volunteer activities include serving a local food pantry, assisting a number or non-for-profit organizations and fundraising for Bulgarian unprivileged children.

She presents at the annual conferences as a member of Academy of Eating Disorders.


Brian E. Martens, L.S.W., M.S.

As a Research Investigator for the Research Institute at Lindner Center of HOPE, Mr. Martens serves as a lead and co-investigator, supervisor and coordinator for numerous clinical trials examining subjects with bipolar disorder. His main research interests are in the area of bipolar disorder.

Prior to joining the Research Institute at Lindner Center of HOPE, Mr. Martens served as a Principal Research Assistant with the Psychopharmacology Research Program at University of Cincinnati Medical Center.

Mr. Martens has co-authored original research on the topics of treatment of acute bipolar depression and the management of eating disorders. He recently presented a poster at the American Psychiatric Association (APA) Annual Meeting as it relates to medication in the treatment of bipolar spectrum disorder with moderate to severe hypomania or mild mania.

As the Research Team Leader, Mr. Martens is also responsible for supervising and training of research assistants, facilitating data entry of study data, marketing current bipolar clinical trials, and interfacing with the institutional review board for ongoing study approval. While working with Dr. McElroy over the past six years, Mr. Martens has been the lead coordinator on over 20 research studies.

Research Institute – Research Personnel

Diane Monahan
Research Institute Office Coordinator
Phone: (513) 536-0716
Email: diane.monahan@lindnercenter.org


Nicole Mori, RN, MSN, APRN-BC
Research Advanced Practice Nurse
Phone: (513) 536-0712
Email: nicole.mori@lindnercenter.org


Anna I. Guerdjikova, PhD, LISW
Research Investigator
Phone: (513) 536-0721
Email: anna.guerdjikova@lindnercenter.org


Brian E. Martens, L.S.W., M.S.
Research Investigator
Phone: (513) 536-0720
Email: brian.martens@lindnercenter.org


Lisa Mundo, MA
Clinical Research Assistant
Phone: (513) 536-0731
Email: lisa.mundo@lindnercenter.org


Stephanie Williams, MS
Clinical Research Assistant
Phone: (513) 536-0704
Email: Stephanie.williams@lindnercenter.org


Genie Groff, BA
Research Program Manager
Phone: (513) 536-0715
Email: genie.groff@lindnercenter.org

Recently Published Research

The Lindner Center of HOPE’s research staff is comprised of nationally and internationally regarded clinical scientists. Each Lindner Center of HOPE researcher has published extensively on a variety of topics.

Paul E. Keck,Jr. MD, President and CEO

Susan L. McElroy, MD, Chief Research Officer


4/16/2015

Mixed Depression in Bipolar Disorder: Prevalence Rate and Clinical Correlates During Naturalistic Follow-Up in the Stanley Bipolar Network.

Susan L. McElroy, MD

Relatively little is known about the co-occurrence of bipolar and eating disorders. We therefore assessed the prevalence and clinical correlates of eating disorders in 875 patients with bipolar disorder.

Source: Journal of Affective Disorders

Read more >


8/11/2010

Prevalence and correlates of eating disorders in 875 patients with bipolar disorder

Susan L. McElroy, MD

Relatively little is known about the co-occurrence of bipolar and eating disorders. We therefore assessed the prevalence and clinical correlates of eating disorders in 875 patients with bipolar disorder.

Source: Journal of Affective Disorders

Read more >


2/1/2010

A Double-Blind, Placebo-Controlled Study of Quetiapine and Paroxetine as Monotherapy in Adults With Bipolar Depression (EMBOLDEN II)

Susan L. McElroy, MD; Richard H. Weisler, MD; William Chang, PhD; Bengt Olausson, MD; Björn Paulsson, MD; Martin Brecher, MD; Vasavan Agambaram, MD;…

The aim of this study was to evaluate the efficacy and tolerability of quetiapine and paroxetine monotherapy for major depression and bipolar disorder.

Source: psychiatrist.com

Read more >


1/1/2010

Sodium Oxybate in the Treatment of Binge Eating Disorder: An Open-Label, Prospective Study

Susan L. McElroy, MD, Anna I. Guerdjikova, PhD, Erin L. Winstanley, PhD, Anne M. O’Melia, MD, Nicole Mori, CNP, Paul E. Keck Jr., MD James I. Hudson, MD, ScD

To assess preliminarily the effectiveness of sodium oxybate in binge eating disorder.

Source: International Journal of Eating Disorders

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11/1/2009

Role of Antiepileptic Drugs in the Management of Eating Disorders

Susan L. McElroy, Anna I. Guerdjikova, Brian Martens, Paul E. Keck Jr, Harrison G. Pope and James I. Hudson

Growing evidence suggests that antiepileptic drugs (AEDs) may be useful in managing some eating disorders. In the present paper, we provide a brief overview of eating disorders, the rationale for using AEDs in the treatment of these disorders and review the data supporting the effectiveness of specific AEDs in the treatment of patients with eating disorders. In addition, the potential mechanisms of action of AEDs in these conditions are discussed.

Source: CNS Drugs

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1/1/2009

Obesity in Patients With Severe Mental Illness: Overview and Management Susan L. McElroy, MD

Obesity and overweight are growing health concerns for the general population and a rapidly increasing concern for clinical populations, particularly patients with severe mental illnesses such as schizophrenia and bipolar disorder.

Source: psychiatrist.com

Read more >


8/1/2008

Binge Eating Disorder Pharmacotherapy Clinical Trails—Who Is Left Out?

Anna I. Guerdjikova & Susan L. McElroy

This report examined the characteristics of subjects interested in binge eating disorder (BED) pharmacotherapy trails who were ineligible for participation.

Source: Wiley InterScience

Read more >


3/1/2008

Olanzapine in the Treatment of Pathological Gambling: A Negative Randomized Placebo-Controlled Trial

Susan L. McElroy, M.D.; Erik B. Nelson, M.D.; Jeffrey A. Welge, Ph.D.; Laura Kaehler, B.A.; and Paul E. Keck, Jr., M.D.

Pathological gambling is associated with bipolar disorder and dopamine dysfunction. Olanzapine is a second-generation antipsychotic with mood-stabilizing properties and antagonistic activity at several dopamine receptors. The purpose of this study was to evaluate olanzapine in the treatment of pathological gambling.

Source: psychiatrist.com

Read more >

Research Careers

Lindner Center of HOPE is affiliated with the Department of Psychiatry at the University of Cincinnati and presents a unique opportunity to work within a community-based setting, committed to the integration of research and treatment. Not only does this bridge between research and treatment enhance treatment options for patients, but it also creates an exciting environment for researchers who are eager to see their findings more immediately benefiting patients and validating the work.

Researchers at Lindner Center of HOPE are members of an interdisciplinary team of clinicians and clinician-scientists who are interested in advancing psychiatric practice. Lindner Center of HOPE researchers will have an academic appointment in the Department of Psychiatry and, as may be appropriate, a joint appointment in the Institute for the Study of Health or the Department of Public Health Sciences.


Please view the Careers Page for a list of current opportunities

Lindner Center of Hope Research Institute

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